What if you create a truly unique routing profile that's wildly different from the common ones for which shortcuts were pre-calculated? The system is smart. If it detects that too many shortcuts (~50, for example) need on-the-fly recalculation and deviate significantly, it might determine that falling back to the original, comprehensive A* algorithm for the entire route would actually be faster than doing many small, heavily modified A* calculations.
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4In 2007, Barrangou et al. demonstrated for the first time the function of CRISPR/Cas9 as a defensive mechanism of bacteria against bacteriophage attacks by a technique called “plaquing” which builds upon the technique of “plating” bacteria on agar. Plaques of viruses on agar are areas without growth of bacteria due to viral attacks.